A genetic analysis of somitogenesis in the Medaka (Oryzias latipes)
نویسندگان
چکیده
1 1. INTRODUCTION 3 1.1 Somite formation in vertebrates 3 1.2 The different steps of somitogenesis 4 1.3 The molecular factors regulating prepatterning of the presomitic mesoderm (PSM) 6 1.3.1 The intrinsic clock in the PSM of vertebrates 6 1.3.2. The role of Notch/Delta signaling in PSM prepatterning 7 1.3.3. The components of the Wave front activity 9 1.4 Setting up Anterior-posterior polarity in the anterior region of the presomitic mesoderm 14 1.4.1. Notch/Delta signaling regulates A-P polarity of somitomeres 14 1.4.2. The function of mesp in setting up anterior-posterior identity 14 1.5 Epithelialization: Formation of morphologically distinct somite boundaries 15 1.5.1. The Eph signaling and its role during boundary formation 15 1.5.2. Fibronectin and its role during somite boundary formation 16 1.5.3. The role of Cadherins during somite boundary formation 16 1.5.4. The involvement of paraxis in the boundary formation step 17 1.6 Fish as model systems to study somitogenesis 18 1.6.1. Zebrafish as an established model to analyze somitogenesis in vertebrates 19 1.6.2. Medaka as a new complementary model to study somitogenesis in vertebrates 22 3.4 Medaka candidates for FGF signaling pathway mutants 45 3.4.1 Doppelkorn (Dpk) as a potential candidate for an FGF pathway mutant 45 3.4.2 Schnelles ende (sne) as a potential candidate mutant in the fgfr1 gene 46
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